Now, erectile dysfunction is a very widespread disorder in men. Unfortunate schedule of life is responsible for the modification of physiological changes in the human body. Several conditions are responsible for the state of impotence or erectile dysfunction. Too much consumption of alcohol and consumption of other narcotic drugs are accountable for the condition of erectile dysfunction in men. You should not take it in excessive amount or you should reduce the amount of alcohol to avoid the situation of impotence.
People who smoke in the excessive amount are more prone to the disease of erectile dysfunction. Smoking is a very big problem, which may cause impotence in men. Under certain medical conditions such as heart disease, diabetes mellitus, hepatic failure, and renal failure, erection cannot be achieved properly. So treat your medical conditions to overcome the condition of erectile dysfunction. People suffering from depression, anxiety, or panic disorders are also prone to the condition of erectile dysfunction.
How Tadalafil acts?
Generic Tadalafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penile. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by Tadalafil enhances erectile function by increasing the amount of cGMP.
Dosage regimen for Tadalafil-
Tadalafil is available in various strength of 20mg, 40mg and 60mg strength which to be taken orally 30-40 minutes before the planned sexual activity. Various Brand names are available for Tadalafil such as Cialis, Tadaga, Tadacip, and Tadagra. The effect of the drug lasts for about 36 hours after intake of the medication. Do not crush or chew the tablet; swallow it as a whole. However, some side effects are likely to occur while using this medication such as a headache, nausea, vomiting, drowsiness and painful erection.
There are some precautionary measures which needs to be kept in mind while using this medication such as-
- Do not take this medication if you are hypersensitive to the active ingredient Tadalafil;
- To be avoided in case of any cardiac disorder, liver or kidney damage issues;
- Avoid use of grapefruit juice and alcohol with this medication as it can increase the adverse effect of the drug;
- Use of some antibiotics can increase the chances of side effects so avoid the use of antibiotics along with this medication.
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