Tadalafil like other erectile products is a phosphodiesterase 5 inhibitor.During the process of sexual stimulation Tadalafil inhibits the activity of Phosphodiesterase type 5 (PDE5). With normal sexual stimulation there is a release of nitric oxide from the nerve endings and endothelial cell in the corpus cavernosum which leads to increased levels of cGMP in the corpus cavernosum and hence a better erections. NextNitric oxide is believed to convert the guanylate enzyme to cyclic guanosine monophosphate in the smooth muscles of corpus cavernosum. Without sexual stimulation and no activation of the NO/cGMP system, tadalafil should not cause an erection.
What are the possible side effects observed?
The possible side effects which are commonly observed in case of Tadalafil include belching, heartburn, indigestion and stomach upset. The less common side effect include body aches, eye pain, fever, loose stools, neck pain, stomach upset, swollen joints, voice changes and watering of the eyes.
Some of the precautions
Before taking Tadalafil certain parameters requires attention which includes
If you have any heart disease or coronary artery disease you should discuss the same with your physician before using the product.
Those who have met with a stroke in last five to six month should give all the information to the doctor.
When there are heart related disease like angina, low and high blood pressure, share the reports with the doctors.
If you are suffering from some bleeding disorder such as hemophilia, then you should be immediately discussed with the doctor.
Physical deformation of penis should be discussed with the doctor before you start the medication.
There are many blood cell disorders such as sickle cell anemia or leukemia should be discussed with the doctor.
Due to ill health if the doctor has not allowed to have sex, then discuss with your doctor before using the medication.
There is always some reason of withholding a medical treatment. In case of Tadalafil the medicine is contraindicated in case
If you are hypersensitive to any ingredient of the tadalafil 40 mg stop the medication immediately.
If you are using any form of organic nitrate then Tadalafil is strictly contraindicated.
If you ever had an erection which lasted for more than four hours and more during sexual interaction then tadalafil is strictly contraindicated.
Tadalafil has reported drug interaction in certain cases like
When tadalafil is given along with any nitrate drugs, hypotensive effects of nitrates are seen.
When Tadalafil is co administered with alpha blockers have reported sudden lowering of the blood pressure.
When alcohol is taken along with Tadalafil both have mild vasodilating effect which ultimately results into lowering of blood pressure.
Antacid along with Tadalafil have resulted in reduced absorption of Tadalafil.
In case of overdose the symptoms may include severe chest pain, prolonged erection, severe dizziness and persistent back pain or muscle pain.
What happens if I miss a dose?
In case you are taking tadalafil every day and you have missed a dose, and then take the missed dose as soon as you remember. The dose could be missed if it is almost time for your next scheduled dose. If you take extra medicine to make up the missed dose it is never suggested and could be harmful.
The medication should be stored in a cool and dark place and should not be exposed to the light directly. The medication should be kept in such a way that it could be prevented from heat and moisture. Tadalafil should be kept away from children and pets.
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