Disulfiram is non-toxic itself. If it is taken with alcohol, it alters certain steps in the breakdown of alcohol. When alcohol is ingested, it is converted to a chemical called acetaldehyde. Acetaldehyde is further broken down into acetate. For acetaldehyde to be fragmented down into smaller components acetate, it requires the aldehyde dehydrogenase enzymes to acts upon it. Disulfiram is a blocker of aldehyde dehydrogenase inhibitor. Since disulfiram ceases the activity of aldehyde dehydrogenase thus the breakdown of the acetaldehyde is hampered. As a result of which the levels of acetaldehyde become greater as compared to normal levels. This causes the uncomfortable things that boost the person to evade alcohol.
Uses of Dizone:
This drug is used sideways with counseling and support to treat alcoholism. Disulfiram works by hindering the treating method of alcohol in the body. This causes you to have a wicked reaction when you drink alcohol.
Doses and method of administration:
500 mg daily is given in a single dose for one to two weeks in the first phase of treatment. Disulfiram may be taken on retiring by patients who experience a sedative effect.
Side effects of drug:
Drowsiness, tiredness, headache, acne, and metallic /garlic-like flavor in the mouth may occur as body gets used to the medication. If any of these effects persist or worsen, inform to doctor promptly.
The serious side effects that can occur: lessened sexual ability, vision alterations, numbness/burning of arms /legs, muscle feebleness, mental/mood fluctuations (e.g., agitation, thrilling excitement/ confusion), convulsion
This drug may occasionally cause rarely serious liver disease.
Contraindications of Dizone:
Patients receiving or have recently received tinidazole, paraldehyde, alcohol, or alcoholic preparations should not be given Disulfiram.
Drug interactions of Dizone:
Disulfiram in combination with isoniazid, MAO inhibitors (such as phenelzide and tranylcypromine), and metronidazole, omeprazole and tricyclic antidepressants may give antagonistic effects on CNS system of the body.
Disulfiram may increase the amount of the level of certain medicines like theophylline and phenytoin in the body.
Never use Disulfiram with tranylcypromine and amprenavir oral solution.
Disulfiram may respond even with small quantities of alcohol found in over-the-counter cough and cold preparations and any other medications that comes in an elixir form.
Precautions of Dizone:
Before takingdisulfiram,it should be told to the doctor if a person is allergic to it or to thiuram or thiuram-related chemicals (found in pesticides and rubber).
This drug may comprise inactive ingredients, which can cause hypersensitive reactions or other problems.
Prior taking this medication, a doctor should be informed if person have severe heart/blood vessel disease (e.g., coronary artery disease), certain mental/mood condition (psychosis).
Alcoholic beverages or alcohol-containing products/foods (e.g., cough and cold syrups, mouthwash, aftershave) should be avoided while taking this medication.
If a dose is missed, it should be taken as remember. If it is near the time of the next dose, skip the missed dose and resume usual dosing schedule.
Over Dose of Dizone:
Overdosing should not be done. In case of any serious side effects, visit to the nearest doctor.
Storage Conditions for Dizone:
Disulfiram should be stored at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Keep away from heat, moisture, and light. It should not store in the bathroom and should be kept out of the reach of children and away from pets.