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Esbriet generic Pirfenidone

Esbriet generic Pirfenidone

Esbriet is an Anti fibrotic drug   used to treat lung disease called Idiopathic pulmonary Fibrosis (IPF). It works by reducing lung fibrosis through down regulation of the production of growth factors and procollagens I and II. Idiopathic pulmonary Fibrosis (IPF) is chronic and is characterized by progressive decline in lungs function. Pulmonary fibrosis means scarring of lung tissue and is caused by worsening dyspnea (shortness of breath). IPF occurs in individuals between 50 and 70 years of age.

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Quantity Strength Price Unit Price Cart
30 Pills Pirfenidone 200 mg $62.00 $2.07
90 Pills Pirfenidone 200 mg $180.00 $2.00

The mechanism of action of Pirfenidone, the active substance in Esbriet, is not fully understood, but it has been shown to reduce the production of fibroblasts and other substances involved in the formation of hard fibrous tissue during the body’s tissue repair process, thereby slowing down the progression of the disease in IPF patients.


The dose of Esbriet is one capsule three times a day. The dose remains the same for first seven days. From the eight day onwards the dose is two capsules, three times a day. The maintenance dose starts from the fifteenth day and it is three capsules orally three times a day.

Side effects

There are many side effects seen in case of Esbriet. If you have:

  • severe ongoing stomach pain, vomiting, diarrhea;

  • burning or pain in your esophagus or throat;

  • easy bruising or bleeding (nosebleeds, bleeding gums); or

  • Liver  disease

  • nausea

  • upper stomach pain

  • Itching

  • tired feeling

  • loss of appetite

  • dark urine

  • clay-colored stools

  • jaundice


There are unwanted effects which are Common in nature and may include:

  • nausea, vomiting, loss of appetite;

  • stomach pain, heartburn, upset stomach;

  • diarrhea

  • headache, dizziness, tired feeling;

  • weight loss

  • cold symptoms such as stuffy nose, sneezing, sore throat;

  • sleeping problem

  • joint pain

  • Abnormal liver function tests.



Before taking the medication various precautions are required. It includes

  • Patients who are taking Esbriet have a higher incidence of Photosensitivity when exposed to sunlight.

  • In patients who were put on Esbriet gastrointestinal event like nausea and diarrhea were reported.

  • Make sure that if you have any conditions of liver disease, kidney disease or stomach disorder such as gastro esophageal refluxes disease. In such conditions, take the advice of the doctor before starting with the pills.

  • In case of pregnancy or if you are planning to have a baby discuss with your doctor.

  • The women should not breast feed in case she is using Esbriet.


The drug should not be prescribed in case

  • The patient is having hypersensitivity to the active substance or to any of the excipients of the medication.

  • In case of history of angioedema

  • Concomitant use of fluvoxamine should be avoided .

  • In case of severe hepatic impairment or end stage liver disease


 Missed dose

In case of missed dose, take the dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Extra medication should not be taken to make up the doses.


In case of overdose call the doctor immediately and seek medical attention immediately.  


The medication should be stored in a cool and dry place. It should be stored away from children and pets. The medication should be stored below 30 degree Celsius.

Generic Pirfenidone
Strength Esbriet - Pirfenidone 200 mg

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