Feldene inhibits the activity of both Cyclooxygenase -1 (COX-1) and Cyclooxygenase-2 (COX-2) and thereby the synthesis of prostaglandins. The medication is also reported to inhibit the migration of leukocytes into sites of inflammation and prevents the formation of Thromboxanes. Feldene by inhibiting the enzyme activity actually lowers the concentration of Prostaglandins consequently reducing pain, fever and inflammation.
The dose recommended in case of rheumatoid arthritis and osteoarthritis is initially’ with 20 mg once a day. In case of liver impairment take the advice of your doctor. Moreover, if you want to change the dose of the medication you need to take the advice of the doctor.
The side effects could be categorized on the basis of its occurrence. It could be either a common occurrence, less common side effects and rare side effects. The more common side effects which are commonly occurring includes cloudy urine, constipation, headache, heartburn, indigestion, loss of appetite, pale skin, skin rash, swelling, unusual bleeding or bruising and weight loss. The less occurring side effects includes blurred vision, bloody nose, chest pain, confusion, dilated neck veins, dizziness, extreme fatigue, frequent urge to urine and peeling of the skin. There are some side effects which occur rarely and it includes anxiety, cold sweats, cracks in the skin, flushed dry skin, general body swelling, increased hunger and increased urination.
Precaution prevents happening of adverse medical reaction and adverse events. So before taking Feldene
Check with your doctor if you are pregnant, planning to become pregnant or are breast feeding.
There are many other medical complications which are ongoing, when you plan to take Feldene. In such a case you should disclose all the prescription and nonprescription medication which you are planning to take.
Check whether there is a history of kidney, liver, stomach or bowel problems before you start taking the medicine.
In case of high blood pressure, bleeding or clotting problem, heart problems discuss with your doctor before you start taking the drug.
In case of poor health, dehydration or low sodium levels or in case of history of alcohol overuse discuss with your doctor before you start taking Feldene.
Whenever there is a history of asthma or Asthma related disease avoid using the medication.
In case you are allergic to any ingredient of Feldene stop using it immediately.
In case you have a severe allergic reaction reported with any other NSAID like ibuprofen or Celecoxib.
When a person is planning to have a heart surgery or has undergone a surgery, the medication is strictly contraindicated.
When you are in the last three months of pregnancy, you should not consume the medication.
In case of stomach or bowel bleeding, the medication is not prescribed.
In case of overdose, call the doctor immediately and seek medical attention. The symptoms of overdose could be severe nausea or stomach pain, seizures, slow or troubled breathing and vomit which looks like a coffee ground.
The medication if missed should be taken as soon as you remember. However when it’s time for the next dose avoid the missed dose and go for the scheduled dosage.
The medication should be stored below thirty degree Celsius. Excessive heat and moisture is not good for the medication as it affects the stability factor. The medication should not be stored in the bathroom. It should be kept away from children and pets.
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