Azithromycin binds to the 50 S subunit of the 70S bacterial ribosome, and therefore inhibits RNA-dependent protein synthesis in bacterial cells. Zithromax belongs to a class of antibiotic called Macrolide which are bacteriostatic. They are used to treat infection by preventing bacteria from multiplying and producing the proteins that are essential for their growth. Azithromycin gets picked up by white blood cells that fight bacteria. The white blood cells take the medicine to the front lines of their struggle with germs, where it becomes concentrated in the tissues surrounding the infection.
Adult Dose for Mycoplasma Pneumonia: In case of acquired pneumonia the
oral dose include immediate-release tablets of 500 mg orally on the first day. It is followed by 250 mg orally once a day on days 2 through 5 for mild infections.
Adult Dose for Pneumonia: The initial dose is 500 mg orally as a single dose on the first day followed by 250 mg orally once a day on days 2 through 5 for mild infections.
Adult Dose for Tonsillitis/Pharyngitis
The dose includes immediate releasing tablet of 500 mg orally as a single dose on the first day followed by 250 mg orally once a day on days 2 through 5 for mild infection.
Adult Dose for Sinusitis:
The dose includes immediate releasing tablet of 500 mg orally once a day for 3 days for mild to moderate infections
Adult Dose for Skin and Structure Infection
In case of uncomplicated case of skin infection the dose includes immediate releasing tablet of 500 mg orally as a single dose on the first day followed by 250 mg orally once a day on days 2 through 5 for mild infection.
As Azithromycin is excreted from the liver, caution should be taken when the medication is administered to patient with liver disease.
If you have any kidney disease or any renal disorder discuss with your doctor before taking the medication.
In case of any heart disease and patients having history of heart disease, you should discuss with their doctor.
Tell your doctor if you are pregnant or planning to become pregnant.
If you are breast feeding there are chances that the drug may pass through the milk to the baby. So discuss with your doctor.
If you are planning to have any surgeries, tell your doctor before you plan to take the medicine.
If you have myasthenia gravis talk to your doctor.
Aluminum- and magnesium-containing antacids reduce the peak serum levels rate of Azithromycin (500 mg) absorption.
When a single oral dose of 1200 mg Azithromycin (2 × 600 mg Zithromax tablets) is co administered with Nelfinavir 750 mg to healthy adult subjects produced a decrease of approximately 15% in mean area under curve (AUC) of Nelfinavir and its M8 metabolite.
Elevated Digoxin levels are seen in plasma when co administered with Azithromycin.
In case of a missed dose, take it as soon as you remember. You can skip the missed dose if it is almost time for your next scheduled dose. Extra medicine should not be taken to make up the missed dose.
In case of overdose call your doctor immediately and seek medical attention. The symptoms of overdose may be nausea, vomiting, diarrhea and stomach discomfort.
The medication should be stored below 30 degrees Celsius. It should be kept in a cool and dry place. It should be kept away from children and pets.